Molecular mechanisms of aflatoxin B1 hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Promotion of aflatoxin B1-induced hepatocarcinogenesis by dichlorodiphenyl trichloroethane (DDT).
A study of the effect in rats of dichlorodiphenyl trichloroethane (DDT) on hepatocarcinogenesis that is initated by aflatoxin B1 (AFB1). In the first experiment, Buffalo rats were given a single oral dose of AFB1 (5 mg/kg) followed by dietary DDT (100 ppm) for 20 weeks. Neoplastic nodules were observed in 1 of the 14 AFB1-exposed rats, compared with 3 of the 19 rats in the AFB1/DDT group. In th...
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Aflatoxin l (AFB1) is a potent carcinogen for the liver of many experimental animals, and has recently been classified as a human carcinogen on the basis of experimental data and epidemiologic studies in exposed human populations. Covalent binding to DNA resulting from metabolic activation to the 9, 10 oxide is considered to be a critical initiating event in the carcinogenesis process. Total le...
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Experiments were designed to determine the in vivo effects of a single 6-mg/kg dose aflatoxin B1 on rat liver mitochondrial transcription and translation processes. With the use of intact hepatocytes and also a highly active mitoplast system for incorporation, it was observed that both mitochondrial transcription and translation activities are inhibited progressively even after 24 hr of carcino...
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The rice bran or outer layer of the rice grain contains a number of micronutrients and valuable phytochemicals. Several studies have shown that pigmented rice bran contains higher amounts of beneficial phytochemicals such as phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, phytic acid, free fatty acids and methyl ester derivatives (Leardkamolka...
متن کاملSynergistic effect of hepatitis B virus and aflatoxin B1 in hepatocarcinogenesis in tree shrews.
An animal experiment with tree shrews was performed to detect the synergistic effects of hepatitis B virus (HBV) infection and dietary aflatoxin B1 (AFB1) in hepatocarcinogenesis. Adult healthy tree shrews (Tupaia belangeri chinensis) were divided into four groups: Group A (HBV + AFB1)--animals were infected with human HBV serum at first, then fed AFB1 diluted with milk, 150 ug/kg.bw/day, 6 day...
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ژورنال
عنوان ژورنال: Mycotoxins
سال: 2005
ISSN: 0285-1466,1881-0128
DOI: 10.2520/myco.55.149